Glyoxals as in vivo RNA structural probes of guanine base-pairing
نویسندگان
چکیده
منابع مشابه
Base pairing constraints drive structural epistasis in ribosomal RNA sequences.
It has long been accepted that the structural constraints stemming from the 3D structure of ribosomal RNA (rRNA) lead to coevolution through compensating mutations between interacting sites. State-of-the-art methods for detecting coevolving sites, however, while reaching high levels of specificity and sensitivity for Watson-Crick (WC) pairs of the helices defining the secondary structure, only ...
متن کاملRNA-RNA base-pairing: theme and variations.
A row of small white volumes marches along one bookshelf in my cluttered office. It is flanked on both ends by slightly larger volumes. The first is labeled “Processing of RNA, Brookhaven Symposia in Biology, Number 26,” the proceedings of a meeting I attended in May, 1974, as a relatively new assistant professor with my undergraduate student David Ginsburg. The other larger volume is “RNA ’96,...
متن کاملDeconvolving RNA Base Pairing Signals
The structure of an RNA sequence encodes information about its biological function. A sequence is typically predicted to fold to a single minimum free energy conformation. But, an increasing number of RNA molecules are now known to fold into multiple stable structures. Discrete optimization methods are commonly used to predict foldings, and adding experimental data as auxiliary information impr...
متن کاملAlignment of RNA base pairing probability matrices
MOTIVATION Many classes of functional RNA molecules are characterized by highly conserved secondary structures but little detectable sequence similarity. Reliable multiple alignments can therefore be constructed only when the shared structural features are taken into account. Since multiple alignments are used as input for many subsequent methods of data analysis, structure-based alignments are...
متن کاملA New Base-Modified Deoxycytidine Capable of Base Pairing With Guanine Using Four Hydrogen Bonds
Content Synthetic scheme of phosphoramidite 9b ------------------------------------------------------------------S3 Figure S1 ------------------------------------------------------------------------------------------------------S4 Figure S2 ------------------------------------------------------------------------------------------------------S4 Figure S3 -----------------------------------------...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RNA
سال: 2017
ISSN: 1355-8382,1469-9001
DOI: 10.1261/rna.064014.117